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Lazio suffered their heaviest home defeat in history while champions Inter Milan won 6-0 in Rome.
Lazio started the night level on points with Inter and top of the Europa League table, but had no answer to Simone Inzaghi’s stunning attacking play.
They were unbeaten in 12 home games and hadn’t lost in front of their own fans since March.
Hakan Calhanoglu gave Inter the lead from the penalty spot in the 41st minute, after a penalty awarded for handball, and Federico Dimarco doubled the lead before the break with a volley.
Nicolo Barella struck to make it 3-0 six minutes from the restart before Denzel Dumfries struck two minutes later and Carlos Augusto and Marcus Thuram completed the rout in the second half.
Inter remained third in the standings with 34 points from 15 matches and trailed leaders Atalanta by three points with a game in hand.
Lazio’s previous record home defeat was a 5-0 loss to Fiorentina in 1959.
Their three biggest defeats in Serie A have all come against Internazionale: this defeat comes after 8-1 (1934) and 7-0 (1961) defeats in Milan.
